Caffeic acid phenethyl ester

Caffeic acid phenethyl ester


Caffeic acid phenethyl ester powder (CAPE) is the active component of propolis, a honeybee hive product.[6] Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.[1] CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.[5][7] Caffeic acid phenethyl ester inhibits HIV-1 integrase,[3][2] and also inhibits proliferation of transformed cells.[9][4] It induces apoptosis in transformed fibroblasts,[8] and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.[9]
Biochem/physiol Actions
Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor NF-κB.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

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