Archiv für den Monat: Oktober 2019

Lieel Icos Cialis tadalafil 80mg and 100mg tablets

The Therapeutic Goods Administration (TGA) has tested products labelled Lieel Icos Cialis tadalafil 80mg and 100mg tablets (as compared to Lilly on genuine Cialis tablet products) and found that:Tadalafil powder half life
Lieel Icos Cialis tadalafil: image of grey box packagingthe tablets did not contain the stated substance tadalafil.
the tablets contain the undeclared substance sildenafil.
consumers are advised that sildenafil is a prescription-only medicine.
The supply of Lieel Icos Cialis 80mg and 100mg tadalafil tablets is illegal.

Lieel Icos Cialis tadalafil 80mg and 100mg tablets have not been assessed by the TGA for quality, safety or efficacy as required under Australian legislation, and the place of manufacture is not approved by the TGA.

Lieel Icos Cialis tadalafil: image of blue box packagingTGA investigations have shown that a number of people in Australia may have bought the products online.
The TGA is working with Australian Customs and Border Protection Service (ACBPS) to help stop future shipments of Lieel Icos Cialis 80mg and 100mg tadalafil tablets from entering Australia.

If these tablets are found at the border by ACBPS they will be seized and destroyed.

The TGA is advising consumers to exercise extreme caution when purchasing medicines from unknown overseas Internet sites. Products purchased over the Internet:

What’s right for me, Sildenafil or Tadalafil?

If you’re considering medication to improve your erections and sexual experiences, you’ve probably heard about the two most popular active ingredients, Sildenafil and Tadalafil. Sildenafil is the active ingredient popularized by the brand Viagra and is designed to last 4-6 hours. Tadalafil is the active ingredient in Cialis and designed to last 24-36 hours.

These medicines have a lot in common, including a success rate of more than 80 percent. They’ve both been well researched for decades, so you may be wondering which one will give you the best results.buyaas Tadalafil
The 4 things you should know when making your decision.
1 – Consider your plans
When your evening plans with your special someone include dining, it’s important to remember that food can impact how effectively your body absorbs medication. Sildenafil & Tadalafil pills works best on an empty stomach, so it may not be the preferred choice for a night that includes dinner or cocktails. Most troublesome are fatty meals are also a no-no because they can slow the onset of the drug’s active ingredient, meaning you’ll need to delay intercourse. That is one of the main reasons people are choosing chewable tablets that disintegrate in your mouth that are now available at Bluechew.

2 – Timing is everything.
If you’ll be spending more than an evening with your partner and don’t know when the timing is going to be right, you may prefer a drug that has a longer window of opportunity. Tadalafil remains in the body longer, as long as 36 hours in most cases, so there’s no need to rush your time together. This is a big plus, because anxiety and nervousness also can cause Erectile Dysfunction (ED) even when the blood flow is working just fine.

Sildenafil, however, has a short four- to six-hour active time frame, which means you’ll need to plan your time carefully to avoid it wearing off before you need it. Traditionally men have reported Tadalafil working faster than Sildenafil, but with chewables both of them work up to twice as fast as pills, so there is not much to worry about if you choose Bluechew.

3 – Daily dosing or on demand.
For men that want to be able to have sex at any time, Tadalafil might be the better choice. It’s available in lower dose tablets ranging from 2.5 mg. to 20 mg. and advised to be taken daily. Since it stays in your system for 24-36 hours, it gives you more opportunities for spontaneous intercourse whenever you and your partner are in the mood.

Sildenafil, on the other hand, is prescribed for use as needed. It generally takes about an hour before becoming effective in pill, so a little extra patience (and planning) must be taken into consideration. With chewables that hour is greatly reduced to be closer to 30-40 minutes. It also has variable dosing depending on the patient’s needs, from 25 mg. to 100 mg., but it wears off after four to six hours.

4 – Cost is always a factor
Since both medications molecules are off patent, the cost has been reduced considerably from their entry into the market. This is very good news because it shouldn’t cost a fortune to be intimate with your partner. Your particular prescription will be based on the strength of the drug, so, obviously, the higher the dosage, the higher the price will be for you. At Bluechew we try to keep the price reasonable by never charging for a doctors appointment and patient support.

tadalafil for treatment of male erectile dysfunction held invalid

In order to clear the way for the marketing of their own products Actavis, Teva and Mylan applied to revoke an Icos/ Lilly patent directed at the treatment of sexual dysfunction by the administration of a dose of no more than 5mg tadalafil per day. They argued that it would have been obvious for the skilled team to take tadalafil forward into a routine pre-clinical and clinical trial programme to assess its use as an oral treatment for sexual dysfunction. In the course of that programme, a 5mg daily dose of tadalafil would be used in patients and it would reveal the invention, that a 5mg daily dose is a safe, tolerable and effective treatment.Tadalafil powder dosage

Lilly argued the case was really one of “obvious to try” and that this could only lead to a finding of invalidity if the skilled team would consider that the programme had a fair prospect of success. This they disputed because, at the start of the programme, the skilled team would have had no idea whether or not a 5mg daily dose of tadalafil would be a safe, tolerable and effective treatment of sexual dysfunction, still less that it would be both efficacious and have minimal related side effects.

The trial judge agreed with Lilly that the patent was not invalid for obviousness. He found that the skilled team would embark on the project with a reasonable expectation of success in establishing tadalafil as a safe, tolerable and effective treatment, but it would not have been able to predict that the 5mg / day dose would be effective.

The Court of Appeal held this was not a case in which the skilled team would be faced with a series of parallel avenues of study and would not have any expectation that any one of those avenues would prove fruitful or be more likely to prove fruitful than any other. Nor was it a case where most or even some of the avenues of investigation would not lead to the invention. Instead it was a case where the two possibilities of on demand and daily dosing would both be addressed in light of the earlier routine work, and where each would be very likely to lead the skilled team to the invention.

The judge wrongly attached weight to the fact that a dose of 5mg was considerably less than the 50mg dose (disclosed in the prior art) which would be used in Phase IIa efficacy test, and to the fact that a dose of 5mg would not be chosen for the routine first dose ranging study in Phase IIb. The Court of Appeal noted, however, that the two parts of Phase II clinical trials have different purposes. Phase IIa is designed to provide proof of concept and is generally carried out at one dose selected to be high enough to provide the best chance of showing a positive effect while not causing serious side effects. Phase IIb is carried out at different doses chosen to provide an understanding about the dose response relationship. Although a dose of 5mg would not be chosen for the first study in Phase IIb, the skilled but uninventive team would very likely investigate it thereafter. In the course of this it was very likely that they would test a dose of 5mg tadalafil per day and, if they did so, they would find that it is safe and efficacious. At that point they would have arrived at the claimed invention.

The judge had therefore fallen into error. If the only thing driving the skilled team to test the 5mg dose was its level of expectation that a 5mg dose might be effective, expectation of success as to efficacy would be highly material. However, phase IIb clinical tests are conducted with a separate objective, namely to identify a dose response. The absence of an expectation of success as to efficacy was, in these particular circumstances, not relevant.

Although the skilled team would be surprised by the result, namely efficacy at 5mg/day, such a finding would be arrived at by the standard, routine enquiries into dose response which are required by Phase IIb clinical trials. It followed that the surprising result, once uncovered, did not make these routine enquiries inventive.

Expectation of success, if relevant at all, should come in before making the decision on what the skilled team would do. If the skilled team had no expectation of success, that might be a reason why they would not undertake the step in question. But having come to the conclusion that they would, there was no further need to examine an expectation of success.

Amino Tadanafil Powder Sexual pills Amino Tadalafil Powder

Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Tadalafil, and under the name Adcirca for the treatment of pulmonary arterial hypertension.buyaas Tadalafil powder
Tadalafil’s pharmacologic distinction is its longer half-life (17.50 hours) resulting in longer duration of action, and so partly responsible for „The Weekend Pill“ sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil’s daily therapeutic use in relieving pulmonary arterial hypertension.
Betamethasone is a steroid medication.It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis andsystemic lupus erythematosus, skin diseases such as dermatitis andpsoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby’s lungs, Crohn’s disease, cancers such as leukemia, and along with fludrocortisone foradrenocortical insufficiency, among others.It can be taken by mouth,injected into a muscle, or applied as a cream.When given by injection, anti-inflammatory effects begin in around two hours and last for seven days.

Betamethasone was approved for medical use in the United States in 1961.The cream is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication.In the United States the pills and injectable solution are expensive while the cream is not.

Aplication:
1. Betamethasone is a corticosteroid used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination betamethasone/calcipotriol. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids.
2. Betamethasone is also used prior to delivery of a preterm baby to help prepare the lung for breathing

Tadalafil Powder for Sex Enhancement

Model NO.: CAS No.: 171596-29-5
Product Name:buyaas Tadalafil powder
CAS: 171596-29-5
Appearance: White Powder
Function: Men Sex Enhance and Time Extension
Trademark: Huao
Transport Package: Foil Bags
Specification: IOS
HS Code: 3004201911
Effective Tadalafil Powder for Men Sex Enhancement CAS 171596-29-5

Tadalafil is a kind of Male sex hormone product in market , men like it very much . It was oral pills /caps for 10mg , and lasting 72 hours effect …

Product name: Tadalafil
Key words: Tadalafil , anabolic, bodybuilding, steroid powder
Chemical Formula: C22H19N3O4
Molecular Weight: 389.341
CAS No: 171596-29-5
Packing: Foil bag
Quality standard: USP31/BP2005
White Crystalline Powder
Storage: Shading, Confined Preservation
Usage: Can be used as pharmaceutical material. Its main function is to promote metabolism.
Anabolic effects include growth of muscle mass and strength, increased bone density and strength, and stimulation of linear growth and bone maturation.
Delivery: Express courier.
Application:

(tadalafil) relaxes muscles found in the walls of blood vessels and increases blood flow to particular areas of the body.its used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate).We also call it 36 hours . It could work fast within 30 minutes for men .Also it can last longer, approximately 36 hours ,even 72 hours .

it takes PRN, a tablet may help some men get ready for sexual activity within 30 minutes, which means you will work 36 hours. This means that you and your spouse have plenty of time to taste a relaxing dinner date, a weekend holiday or anniversary celebration, but there is plenty of time to choose if your time is right.

Carvedilol „effective and safe“ in severe chronic heart failure

Carvedilol is effective, safe and well tolerated in patients with severe chronic heart failure, according to the results of a recent multinational trial. wisepoqder Carvedilol

The COPERNICUS (carvediol prospective randomised cumulative survival) trial was stopped earlier this year, 12 months ahead of schedule, because of the significant survival benefit seen with carvedilol. All trial patients were offered treatment with carvedilol.
countries enrolled in the study randomly received, as well as standard heart failure treatment, either placebo or carvedilol at a starting dose of 3.125mg twice daily, titrated each week to a dose of 6.25mg, 12.5mg and 25mg twice daily.

Data revealed at the American Heart Association’s conference showed that carvedilol reduced the risk of mortality (all cause) or hospitalisation of patients with severe chronic heart failure by nearly a third (31 per cent). Fewer adverse events and lower withdrawal rates were found with carvedilol compared with placebo.
A previous study of carvedilol, the Carvedilol US Trial Programme, showed a 65 per cent reduction in mortality with carvedilol in patients with mild to moderate heart failure.
In a press release, Roche Pharmaceuticals said that carvedilol was not licensed for treatment of severe heart failure in the UK and that a licence application would be made shortly.

Carvedilol with breast cancer treatment reduces echocardiographic findings

Patients with nonmetastatic HER-2 positive breast cancer and weak markers of HF treated with trastuzumab had reductions in systolic and diastolic echocardiographic findings when concomitantly treated with carvedilol, according to findings presented at EuroEcho-Imaging.wisepoqder Carvedilol powder

Maryam Moshkani Farahani, MD, associate professor at Baqiyatallah University of Medical Sciences in Tehran, Iran, and colleagues analyzed data from 71 patients with nonmetastatic HER-2 positive breast cancer who were eligible for treatment with trastuzumab (Herceptin, Genentech). Patients were either assigned carvedilol with trastuzumab (n = 36) or trastuzumab alone (n = 35). Those who were assigned carvedilol received a standard dosage of 6.25 mg twice per day, which was then up-titrated to the maximally tolerated dose.
Left ventricular systolic and diastolic function were evaluated with speckle-tracking echocardiography at baseline and every 3 months.

During follow-up, mean LV ejection fraction did not differ between both groups (P = .61). Patients assigned trastuzumab alone had reductions in strain rate of LV systolic function (P = .004) and global longitudinal strain of LV (P = 0). Those assigned prophylactic carvedilol had preserved LV strain rate of early (P = 0) and late diastolic function (P = .005).

“Heart damage is a major side effect of the breast cancer drug trastuzumab and may force patients to stop treatment,” Moshkani Farahani said in a press release. “Our study suggests that patients who take the beta-blocker carvedilol together with trastuzumab have less heart damage than those who take trastuzumab alone.”
Zydus Pharmaceuticals USA Inc. is recalling 7668 bottles of carvedilol tablets, 3.125 mg, after a customer found a fragmented tablet of another drug product in a bottle. The recall was announced in the May 1, 2019, US Food and Drug Administration (FDA) Enforcement Report.

The recall is for 500-count bottles from lot Z803518 (Exp. 8/20). Bottles from the affected lot were manufactured by Cadila Healthcare Ltd. and distributed throughout the United States by Zydus Pharmaceuticals.

Zydus Pharmaceuticals voluntarily issued the recall April 22, 2019. On April 25, 2019, the FDA designated the recall Class III, suggesting use of the affected product is unlikely to cause adverse health consequences.Carvedilol is a prescription beta-blocker used to treat heart failure and hypertension.

The Marfan Foundation Statement on Celiprolol

On June 25, 2019, the FDA announced that it has rejected Acer Therapeutics’ application for exclusive use of the third generation beta blocker celiprolol in the US for the treatment of people with vascular Ehlers-Danlos syndrome (vEDS). This is a rare (about 1/50,000 in the US) genetic condition that results from mutations in one copy of the COL3A1 gene (which encodes type III collagen) and is complicated by arterial aneurysm, dissection, and rupture which can lead to premature death.wisepoqder Celiprolol powder

The Marfan Foundation, as well as representatives of its Professional Advisory Board, have reviewed the underlying studies of the drug and agree that celiprolol does not warrant designation as a sole approved drug for the treatment of people with vEDS (see background below). The Foundation recommends that registries of affected individuals with COL3A1 mutations be assembled quickly to facilitate informative clinical trials.

Patients should be aware that there are similar third generation beta-blockers, such as carvedilol, nebivolol, and labetalol, available in the US that are being prescribed off-label for this condition. Both carvedilol and labetalol are generic; therefore, they are very low in cost, and nebivolol will soon come off patent. However, there are no trials or long-term studies utilizing these drugs investigating protective effects in this population.

We suggest that optimal future trial design require molecular confirmation of diagnosis and take into account the type of mutation in a given patient as well as prior medical and surgical history, including vascular events and interventions. The outcomes need to be rigorously defined and ascertained by individuals who are unaware of treatment status in order to avoid bias. The assignment of an individual to the celiprolol or control (no or alternative treatment) group needs to occur at random and be maintained throughout the study.

This proposed prospective, randomized, placebo-controlled, double-blinded, and intention to treat study design is standard in the field and is the most powerful and definitive way to assess for benefit or absence of benefit for celiprolol in vEDS. It is also essential that the study be of sufficient size to reach robust conclusions – including both the number of individuals treated with celiprolol and those receiving placebo or alternative therapy. Alternative medications for testing might include other beta-blockers that are currently available in the US and are inexpensive or other medications that have demonstrated protective effects in animal models. The costs for the trial will be significant, given the nature of surveillance that will probably be needed, and support from multiple sources will have to be obtained.

The Marfan Foundation is eager to assist in protocol design, generation of funds, patient recruitment, and education of both patients and their healthcare providers, as it did with the Pediatric Heart Network Study of the angiotensin-receptor blocker losartan in Marfan syndrome.

CMS 121 FUNDAMENTALS OF FILMMAKING

This introductory course is designed to acquaint students with the basic elements of film production. Students are taught the aesthetics and techniques required for producing a short narrative film. They are also introduced to techniques in producing, writing, cinematography, directing, and editing. Students are required to write, produce, and direct a short film. Note: Students are required to share in the expenses involved in their productions.wisepoqder CMS121
Course Goals: Upon successful completion of this course, students should be able to do the following:
develop a storyboard and script for a short film from an original idea;
utilize cinematographic techniques to convey meaning and create visual interest in a short film;
plan and implement a film shoot with a variety of crew roles; and
edit filmed scenes into a short narrative or experimental film.

Assessing J147 for Alzheimer’s in Healthy Volunteers

This Phase I clinical study will assess the safety and pharmacokinetics of the experimental drug J147 in healthy adults. Researchers are investigating the drug as a potential treatment for Alzheimer’s disease.wisepoqder J147 powder

Exclusion Criteria
History or evidence of heart, endocrine, blood, immune, gastrointestinal, genital, urinary, or other body system disease
History or evidence of disease or dysfunction in neurological or psychiatric system that is likely to affect study results
Any disorder that would interfere with the absorption, distribution, metabolism, or excretion of drugs
Any concurrent disease or condition that would make the participant unsuitable for study participation
Positive for hepatitis B surface antigen, hepatitis C antibody, or HIV antibodies
Positive test for ethanol (alcohol) or cotinine (tobacco) at screening or admission
Positive urine drug test (e.g., cocaine, amphetamines, barbiturates, opiates, benzodiazepines, cannabinoids) at screening or admission
Is unwilling to avoid consumption of grapefruit, Seville oranges, or other products containing grapefruit or Seville oranges within 14 days of taking the study drug
History of alcohol and/or illicit drug abuse in past year or is unwilling to avoid use of alcohol or alcohol-containing foods, medications, or beverages within 48 hours of admission until discharge from the clinical unit
Has donated blood or blood products within 30 days of first dosing
Requires treatment with any prescription drugs or over-the-counter medications, including vitamins (large doses), dietary supplements, or herbal medications, within 14 days of study medication (acetaminophen 1,000 mg per day and recommended daily doses of vitamins are permitted)
Has received any known liver or kidney clearance altering agents (e.g., erythromycin, cimetidine, barbiturates, phenothiazines, or St. John’s wort) within 30 days of study start
Has used an investigational drug within 30 days of screening
Hypersensitivity or allergies to J147, any of its components, or any drug within the same class
Significant abnormal vital signs on physical exam or laboratory results
Is considering or has scheduled any surgical procedure during study participation
Requires a special diet or has a significant food allergy or intolerance (vegetarian diet may be permitted)
Currently enrolled in another clinical study
Evidence of cognitive decline that is greater than expected for participant’s age or changes in level of independence in everyday life
Detailed Description
J147 is a synthetic derivative of curcumin, a component of the curry spice turmeric. In this study participants will be randomly assigned to take either the study drug or a placebo in an escalating dose. Doses will first be given to younger participants after an 8-hour fast. Older participants will then receive doses that have been found to be safe in younger participants.